G-protein coupled receptor 56; protein TM7XN1 (GPR56, TM7LN4, TM7XN1, UNQ540/PRO1083)

Function: - could be involved in cell-cell interactions Structure: - belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily - contains 1 GPS domain Compartment: - cell membrane; multi-pass membrane protein Alternative splicing: named isoforms=2 Expression: - widely distributed - highest levels found in thyroid gland, brain & heart - expressed in MANY tumor cells Pathology: - defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 693 aa MW = 78 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-25} exoplasmic domain {26-402} MOTIF: N-glycosylation site {N39} N-glycosylation site {N148} N-glycosylation site {N171} N-glycosylation site {N234} N-glycosylation site {N303} N-glycosylation site {N324} N-glycosylation site {N341} GPS {343-394} transmembrane domain {403-423} cytoplasmic loop {424-448} transmembrane domain {449-469} exoplasmic loop {470-476} transmembrane domain {477-497} cytoplasmic loop {498-518} transmembrane domain {519-539} exoplasmic loop {540-576} transmembrane domain {577-597} cytoplasmic loop {598-609} transmembrane domain {610-630} exoplasmic loop {631-636} transmembrane domain {637-657} cytoplasmic domain {658-693}

Database Correlations

OMIM correlations MORBIDMAP 604110 UniProt Q9Y653 PFAM correlations Entrez Gene 9289 Kegg hsa:9289