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G protein-coupled receptor GPR44; prostaglandin D2 receptor DP2; chemoattractant receptor-homologous molecule expressed on Th2 cells (PTGDR2, CRTH2, DP2)

Function: - linked to Gi - PGD2 produced by activated mast cells uses CRTH2 to induce intracellular Ca+2 mobilization & chemotaxis in Th2 cells (Gi-alpha-dependent) - CRTH2 also mediates PGD2-dependent migration of blood eosinophils & basophils - activation of CRTH2 (DP2) promoted neuronal loss in hippocampal pyramidal neurons in paradigms of glutamate toxicity; this contrasts with activation of PTGDR (DP1) which promotes neuronal survival Structure: belongs to the G-protein coupled receptor 1 family Expression: - expressed in thalamus, frontal cortex, pons, hippocampus hypothalamus (lower levels), caudate/putamen (lower levels) fetal liver, leukocytes, thymus - selectively expressed in vivo in activated T-helper-2 (Th2) cells, including allergen-responsive Th2 cells, but not in B cells or NK cells

Related

prostaglandin D2 receptor DP1 (Prostanoid DP receptor, PGD receptor)

General

glycoprotein prostaglandin receptor G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 43 kD entity length = 395 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-33} MOTIF: N-glycosylation site {N4} N-glycosylation site {N25} transmembrane domain {34-56} cytoplasmic loop {57-67} transmembrane domain {68-89} exoplasmic loop {90-106} MOTIF: cysteine residue {C104} MODIFICATION: cysteine residue {C182} transmembrane domain {107-127} cytoplasmic loop {128-146} transmembrane domain {147-168} exoplasmic loop {169-210} MOTIF: cysteine residue {C182} MODIFICATION: cysteine residue {C104} transmembrane domain {211-231} cytoplasmic loop {232-247} transmembrane domain {248-269} exoplasmic loop {270-288} transmembrane domain {289-308} cytoplasmic domain {309-395}

Database Correlations

OMIM 604837 UniProt Q9Y5Y4 Pfam PF00001

References

  1. UniProt :accession Q9Y5Y4
  2. Liang X, Wu L, Hand T, Andreasson K. Prostaglandin D2 mediates neuronal protection via the DP1 receptor. J Neurochem. 2005 Feb;92(3):477-86. PMID: 15659218