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free fatty acid receptor 2; G-protein coupled receptor 43 (FFAR2, GPR43)
Function:
- receptor for short chain fatty acids
- actiivty mediated via Gi-protein inhibition of adenylyl cyclase & elevation of intracellular Ca+2
- the rank order affinity for free fatty acids is:
- acetate= propionate = butyrate > pentanoate = formate
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- highly expressed in peripheral blood leukocytes
- lower expression in spleen
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 330 aa
MW = 37 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-12}
transmembrane domain {13-33}
cytoplasmic loop {34-41}
transmembrane domain {42-62}
exoplasmic loop {63-84}
transmembrane domain {85-105}
cytoplasmic loop {106-126}
transmembrane domain {127-147}
exoplasmic loop {148-173}
MOTIF: N-glycosylation site {N151}
N-glycosylation site {N167}
transmembrane domain {174-194}
cytoplasmic loop {195-219}
transmembrane domain {220-240}
exoplasmic loop {241-255}
transmembrane domain {256-276}
cytoplasmic domain {277-330}
Database Correlations
OMIM 603823
UniProt O15552
Pfam PF00001
Entrez Gene 2867
Kegg hsa:2867
References
UniProt :accession O15552