G-protein coupled receptor 42 (GPR42, GPR42P)

Function: - may act as a receptor for short chain fatty acids, such as propionate Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Polymorphism: - sequence differences between GPR42 & FFAR3 are due to polymorphisms Note: - originally thought to be a pseudogene [2]

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 346 aa MW = 39 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-19} transmembrane domain {20-40} cytoplasmic loop {41-47} transmembrane domain {48-68} exoplasmic loop {69-90} transmembrane domain {91-111} cytoplasmic loop {112-132} transmembrane domain {133-153} exoplasmic loop {154-178} MOTIF: N-glycosylation site {N166} transmembrane domain {179-199} cytoplasmic loop {200-222} transmembrane domain {223-243} exoplasmic loop {244-258} transmembrane domain {259-279} cytoplasmic domain {280-346}

Database Correlations

OMIM 603822 UniProt O15529 Pfam PF00001