free fatty acid receptor 3; G-protein coupled receptor 41 (FFAR3, GPR41)

Function: - receptor for short chain fatty acids - activity is coupled to the formation of inositol 1,4,5-trisphosphate, intracellular Ca2+ mobilization, the activation of ERK 1/ERK2 & inhibition of intracellular cAMP accumulation - coupled exclusively to the pertussis toxin-sensitive Gi-alpha &/or Go-alpha - the rank order of affinity for fatty acids is: propionate = pentanoate = butyrate > acetate > formate Structure: - belongs to the G-protein coupled receptor 1 family Compartment: -cell membrane; multi-pass membrane protein Expression: - highest expression in adipose tissue - lower expression across all tissues tested Polymorphism: - sequence differences between FFAR3 & GPR42 are due to polymorphisms - the consensus sequences within the coding regions are identical for the two genes

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 346 aa MW = 39 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-19} transmembrane domain {20-40} cytoplasmic loop {41-47} transmembrane domain {48-68} exoplasmic loop {69-90} transmembrane domain {91-111} cytoplasmic loop {112-132} transmembrane domain {133-153} exoplasmic loop {154-178} MOTIF: N-glycosylation site {N166} transmembrane domain {179-199} cytoplasmic loop {200-222} transmembrane domain {223-243} exoplasmic loop {244-258} transmembrane domain {259-279} cytoplasmic domain {280-346}

Database Correlations

OMIM 603821 UniProt O14843 Pfam PF00001 Entrez Gene 2865 Kegg hsa:2865

References

UniProt :accession O14843