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G-protein coupled receptor 39 (GPR39)
Function:
- Zn+2 acts as a agonist
- mediates action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
- effect is mediated mainly through Gq-alpha & G(12)/G(13) proteins
- involved in regulation of body weight, gastrointestinal motility, hormone secretion & cell death (putative)
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- expressed in many tissues, including the stomach, intestine & hypothalamus
General
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 453 aa
MW = 51 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-25}
MOTIF: cysteine residue {C11}
MODIFICATION: cysteine residue {C191}
Zn+2-binding site
SITE: 17-17
Zn+2-binding site
SITE: 19-19
transmembrane domain {26-46}
cytoplasmic loop {47-71}
transmembrane domain {72-92}
exoplasmic loop {93-109}
MOTIF: cysteine residue {C108}
MODIFICATION: cysteine residue {C210}
transmembrane domain {110-131}
cytoplasmic loop {132-154}
transmembrane domain {155-175}
exoplasmic loop {176-223}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C11}
N-glycosylation site {N192}
N-glycosylation site {N206}
cysteine residue {C210}
MODIFICATION: cysteine residue {C108}
N-glycosylation site {N212}
transmembrane domain {224-243}
cytoplasmic loop {244-280}
transmembrane domain {281-301}
exoplasmic loop {302-321}
transmembrane domain {322-347}
cytoplasmic domain {348-428}
MOTIF: Ser phosphorylation site {S380}
Database Correlations
OMIM 602886
UniProt O43194
Pfam PF00001
Entrez Gene 2863
Kegg hsa:2863
References
UniProt :accession O43194