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G-protein coupled receptor 37; endothelin B receptor-like protein 1; ETBR-LP-1; parkin-associated endothelin receptor-like receptor; PAELR (GPR37)
Function:
- orphan receptor
- may have a functional role in the central nervous system
- ubiquitinated by PARK2 in the presence of UBE2E1 & UBE2L3 in the endoplasmic reticulum
- the unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation & prevents neuronal cell death
- forms a complex with PARK2, STUB1 & HSP70
- the amount of STUB1 in the complex increases during ER stress
- STUB1 promotes the dissociation of HSP70 from PARK2, thus facilitating PARK2-mediated GPR37 ubiquitination
- interacts with PACRG
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane, endoplasmic reticulum membrane
- multi-pass membrane protein
Expression:
- expressed in brain & spinal cord,
- expressed at lower levels in testis, placenta & liver
- not expressed any other tissue
- when overexpressed in cells, tends to become insoluble & unfolded
Pathology:
- accumulation of unfolded GPR37 may lead to dopaminergic neuronal death in juvenile parkinson disease (PDJ)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 613 aa
MW = 67 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-26}
exoplasmic domain {27-265}
MOTIF: N-glycosylation site {N36}
N-glycosylation site {N222}
N-glycosylation site {N239}
transmembrane domain {266-286}
cytoplasmic loop {287-299}
transmembrane domain {300-320}
exoplasmic loop {321-335}
MOTIF: cysteine residue {C334}
MODIFICATION: cysteine residue {C419}
transmembrane domain {336-356}
cytoplasmic loop {357-379}
transmembrane domain {380-400}
exoplasmic loop {401-443}
MOTIF: cysteine residue {C419}
MODIFICATION: cysteine residue {C334}
transmembrane domain {444-464}
cytoplasmic loop {465-493}
transmembrane domain {494-514}
exoplasmic loop {515-531}
transmembrane domain {532-552}
cytoplasmic domain {553-613}
Database Correlations
OMIM 602583
UniProt O15354
Pfam PF00001
Entrez Gene 2861
Kegg hsa:2861
References
UniProt :accession O15354