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G-protein coupled receptor 35; kynurenic acid receptor; KYNA receptor (GPR35)
Function:
- receptor for kynurenic acid, an intermediate in tryptophan metabolism (kynurenine pathway)
- activity is mediated by G-proteins that elicit Ca+2 mobilization & inositol phosphate production through Gq proteins &/or Go proteins
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
- internalized to the cytoplasm after exposure to kynurenic acid
Expression:
- predominantly expressed in immune system & gastrointestinal tissues
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 309 aa
MW = 34 kD
COMPARTMENT: cytoplasm
MOTIF: exoplasmic domain {1-24}
MOTIF: N-glycosylation site {N2}
transmembrane domain {25-45}
cytoplasmic loop {46-56}
transmembrane domain {57-77}
exoplasmic loop {78-90}
MOTIF: cysteine residue {C89}
MODIFICATION: cysteine residue {C162}
transmembrane domain {91-112}
cytoplasmic loop {113-135}
transmembrane domain {136-156}
exoplasmic loop {157-174}
MOTIF: cysteine residue {C162}
MODIFICATION: cysteine residue {C89}
transmembrane domain {175-195}
cytoplasmic loop {196-218}
transmembrane domain {219-239}
exoplasmic loop {240-258}
transmembrane domain {259-279}
cytoplasmic domain {280-309}
Database Correlations
OMIM 602646
UniProt Q9HC97
Pfam PF00001
Entrez Gene 2859
Kegg hsa:2859
References
UniProt :accession Q9HC97