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probable G-protein coupled receptor 3; ACCA orphan receptor (GPR3, ACCA)
Function:
- orphan receptor
- activity is mediated by Gi proteins
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed predominantly in the central nervous system
- expressed at low levels in the lung, kidney, testis, ovary & eye
General
glycoprotein
phosphoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 330 aa
MW = 35 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-42}
MOTIF: N-glycosylation site {N20}
transmembrane domain {43-62}
cytoplasmic loop {63-74}
transmembrane domain {75-98}
exoplasmic loop {99-110}
transmembrane domain {111-132}
cytoplasmic loop {133-153}
transmembrane domain {154-173}
exoplasmic loop {174-198}
MOTIF: cysteine residue {C184}
MODIFICATION: cysteine residue {C259}
transmembrane domain {199-217}
cytoplasmic loop {218-245}
transmembrane domain {246-272}
MOTIF: cysteine residue {C259}
MODIFICATION: cysteine residue {C184}
exoplasmic loop {273-277}
transmembrane domain {278-299}
cytoplasmic domain {300-330}
MOTIF: cysteine residue {C313}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S324}
Ser phosphorylation site {S326}
Ser phosphorylation site {S328}
Database Correlations
OMIM 600241
UniProt P46089
Pfam PF00001
Entrez Gene 2827
Kegg hsa:2827
References
UniProt :accession P46089