Search
G-protein coupled receptor 27; super conserved receptor expressed in brain 1 (GPR27, SREB1)
Function:
- orphan receptor
- possibly, amine-like G-protein coupled receptor
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- highly expressed as a 3.0 kb transcript in brain, ovary, testis, heart, prostate & peripheral Leukocytes
- lower levels in pancreas & small intestine
- a 2.3 kb transcript is found in peripheral blood leukocytes
- in brain regions
a) detected as a 3.0 kb transcript in all regions tested
b) highest levels in the caudate nucleus, putamen, hippocampus & subthalamic nucleus
c) lowest expression in the cerebellum
General
glycoprotein
human longevity protein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 375 aa
MW = 40 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-23}
MOTIF: N-glycosylation site {N3}
transmembrane domain {24-44}
cytoplasmic loop {45-55}
transmembrane domain {56-76}
exoplasmic loop {77-97}
MOTIF: cysteine residue {C95}
MODIFICATION: cysteine residue {C171}
transmembrane domain {98-118}
cytoplasmic loop {119-139}
transmembrane domain {140-160}
exoplasmic loop {161-181}
MOTIF: cysteine residue {C171}
MODIFICATION: cysteine residue {C95}
transmembrane domain {182-202}
cytoplasmic loop {203-285}
transmembrane domain {286-306}
exoplasmic loop {307-320}
transmembrane domain {321-341}
cytoplasmic domain {342-375}
Database Correlations
OMIM 605187
UniProt Q9NS67
Pfam PF00001
Entrez Gene 2850
Kegg hsa:2850
References
UniProt :accession Q9NS67