G protein-coupled receptor 24; melanin-concentrating hormone receptor 1; MCH receptor 1; MCHR-1; MCH-R1; MCH1R; MCH-1R; MCHR; somatostatin receptor-like protein; SLC-1 (GPR24, SLC1, MCHR1)

Function: 1) receptor for melanin-concentrating hormone 2) coupled to both G proteins that inhibit adenylyl cyclase & G proteins that activate phosphoinositide hydrolysis Structure: - belongs to the G-protein coupled receptor 1 family Compartment: membrane Expression: - highest level in brain, especially frontal cortex, hypothalamus - lower levels in the liver, heart

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 44 kD entity length = 402 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-94} transmembrane domain {95-115} cytoplasmic loop {116-128} transmembrane domain {129-149} exoplasmic loop {150-167} transmembrane domain {168-188} cytoplasmic loop {189-210} transmembrane domain {211-231} exoplasmic loop {232-253} transmembrane domain {254-274} cytoplasmic loop {275-305} transmembrane domain {306-326} exoplasmic loop {327-343} transmembrane domain {344-364} cytoplasmic domain {365-402}

Database Correlations

OMIM 601751 UniProt Q99705 Entrez Gene 2847

References

UniProt :accession Q99705