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G-protein coupled receptor 22 (GPR22)
Function:
- orphan receptor
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- expressed in brain regions frontal cortex, caudate, putamen & thalamus
- not expressed in pons, hypothalamus & hippocampus
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 433 aa
MW = 49 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-45}
MOTIF: N-glycosylation site {N16}
transmembrane domain {46-66}
cytoplasmic loop {67-85}
transmembrane domain {86-106}
exoplasmic loop {107-115}
transmembrane domain {116-136}
cytoplasmic loop {137-156}
transmembrane domain {157-177}
exoplasmic loop {178-208}
MOTIF: N-glycosylation site {N192}
transmembrane domain {209-229}
cytoplasmic loop {230-315}
transmembrane domain {316-336}
exoplasmic loop {337-349}
transmembrane domain {350-370}
cytoplasmic domain {371-433}
Database Correlations
OMIM 601910
UniProt Q99680
Pfam PF00001
Entrez Gene 2845
Kegg hsa:2845
References
UniProt :accession Q99680