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G-protein coupled receptor 20 (GPR20)
Function:
- orphan receptor with constitutive Gi signaling activity
- unclear if able to activate cyclic AMP pathway(s)
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- ubiquitous
- highest levels in intestinal tissues
- expression in regions of the brain
a) detected in thalamus, putamen, & caudate,
b) not detected in frontal cortex, pons & hypothalamus
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 358 aa
MW = 39 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-48}
MOTIF: N-glycosylation site {N16}
N-glycosylation site {N26}
transmembrane domain {49-69}
cytoplasmic loop {70-86}
transmembrane domain {87-107}
exoplasmic loop {108-125}
transmembrane domain {126-146}
cytoplasmic loop {147-168}
transmembrane domain {169-189}
exoplasmic loop {190-196}
transmembrane domain {197-217}
cytoplasmic loop {218-238}
transmembrane domain {239-259}
exoplasmic loop {260-275}
transmembrane domain {276-296}
cytoplasmic domain {297-358}
Database Correlations
OMIM 601908
UniProt Q99678
Pfam PF00001
Entrez Gene 2843
Kegg hsa:2843
References
UniProt :accession Q99678