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G-protein coupled receptor 18; N-arachidonyl glycine receptor; NAGly receptor (GPR18, GPCRW)
Function:
- receptor for N-arachidonyl glycine
- activity mediated by G proteins that inhibit adenylyl cyclase
- may contribute to regulation of the immune system
Structure:
- belongs to the G-protein coupled receptor 1 family
Compartment:
- cell membrane; multi-pass membrane protein
Expression:
- most abundant in testis & spleen
- highly expressed in CD4 & CD8-positive T-cells & CD19-positive B-cells
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 331 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-26}
MOTIF: N-glycosylation site {N14}
transmembrane domain {27-47}
cytoplasmic loop {48-56}
transmembrane domain {57-77}
exoplasmic loop {78-95}
MOTIF: cysteine residue {C94}
MODIFICATION: cysteine residue {C172}
transmembrane domain {96-116}
cytoplasmic loop {117-138}
transmembrane domain {139-159}
exoplasmic loop {160-191}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C94}
transmembrane domain {192-212}
cytoplasmic loop {213-232}
transmembrane domain {233-253}
exoplasmic loop {254-268}
transmembrane domain {269-289}
cytoplasmic domain {290-331}
Database Correlations
OMIM 602042
UniProt Q14330
Pfam PF00001
Entrez Gene 2841
Kegg hsa:2841
References
UniProt :accession Q14330