G-protein coupled receptor 17; uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; P2Y-like receptor; R12 (GPR17)

Function: - dual specificity receptor for uracil nucleotides & cysteinyl leukotrienes (CysLTs) - signals through Gi & inhibition of adenylyl cyclase Structure: - belongs to the G-protein coupled receptor 1 family Compartment: - cell membrane; multi-pass membrane protein Alternative splicing: named isoforms=2 Expression: - expressed in brain, kidney, heart & umbilical vein endothelial cells - highest expression in brain Pathology: - may mediate brain damage by nucleotides & CysLTs following ischemia

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 367 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-64} MOTIF: N-glycosylation site {N42} transmembrane domain {65-85} cytoplasmic loop {86-92} transmembrane domain {93-113} exoplasmic loop {114-133} MOTIF: cysteine residue {C132} MODIFICATION: cysteine residue {C209} transmembrane domain {134-154} cytoplasmic loop {155-175} transmembrane domain {176-196} exoplasmic loop {197-223} MOTIF: N-glycosylation site {N204} cysteine residue {C209} MODIFICATION: cysteine residue {C132} transmembrane domain {224-244} cytoplasmic loop {245-260} transmembrane domain {261-281} exoplasmic loop {282-308} MOTIF: N-glycosylation site {N282} transmembrane domain {309-329} cytoplasmic domain {330-367}

Database Correlations

OMIM 603071 UniProt Q13304 Pfam PF00001 Entrez Gene 2840 Kegg hsa:2840

References

UniProt :accession Q13304