G protein-coupled receptor GPR14 (urotensin II receptor, UR-II-R, UTS2R, GPR14)

Function: - high affinity receptor for urotensin-2 & urotensin-2B - activity is mediated by a G-protein that activates a phosphatidylinositol-Ca⁺² second messenger system Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: most abundant expression in the heart & pancreas

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 42 kD entity length = 389 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-54} MOTIF: N-glycosylation site {N29} N-glycosylation site {N33} transmembrane domain {55-77} cytoplasmic loop {78-87} transmembrane domain {88-113} exoplasmic loop {114-124} MOTIF: cysteine residue {C123} MODIFICATION: cysteine residue {C199} transmembrane domain {125-146} cytoplasmic loop {147-167} transmembrane domain {168-186} exoplasmic loop {187-209} MOTIF: cysteine residue {C199} MODIFICATION: cysteine residue {C123} transmembrane domain {210-232} cytoplasmic loop {233-258} transmembrane domain {259-284} exoplasmic loop {285-297} transmembrane domain {298-318} cytoplasmic domain {319-389}

Database Correlations

OMIM 600896 UniProt Q9UKP6 Pfam PF00001 Entrez Gene 2837 Kegg hsa:2837

References

UniProt :accession Q9UKP6