sphingosine 1-phosphate receptor 1; G-protein coupled receptor EDG1; S1P receptor 1; S1P1; sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; endothelial differentiation G-protein coupled receptor 1 (S1PR1, CHEDG1, EDG1)

Function: - receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) - inducible endothelial cell G-protein-coupled receptor - may be involved in processes that regulate differentiation of endothelial cells - seems to be coupled to Gi proteins - S1P-induced endothelial cell migration requires the PKB/AKT1- mediated phosphorylation of Thr-236 within the 3rd intracellular loop of S1PR1 Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed in endothelial cells > vascular smooth muscle cells, fibroblasts, melanocytes, & cells of epithelioid origin - induced by the tumor promoter phorbol 12-myristate 13-acetate in the presence of cycloheximide

General

glycoprotein phosphoprotein sphingosine 1-phosphate receptor; S1P receptor (S1PR)

Properties

SIZE: entity length = 382 aa MW = 43 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-46} MOTIF: N-glycosylation site {N30} N-glycosylation site {N36} transmembrane domain {47-71} cytoplasmic loop {72-78} transmembrane domain {79-107} exoplasmic loop {108-121} transmembrane domain {122-140} cytoplasmic loop {141-159} transmembrane domain {160-185} exoplasmic loop {186-201} transmembrane domain {202-222} cytoplasmic loop {223-255} MOTIF: Thr phosphorylation site {T236} transmembrane domain {256-277} exoplasmic loop {278-293} transmembrane domain {294-314} cytoplasmic domain {315-382} MOTIF: cysteine residue {C328} MODIFICATION: palmitate COMPARTMENT: membrane Ser phosphorylation site {S353}

Database Correlations

OMIM 601974 UniProt P21453 Pfam PF00001

References

UniProt :accession P21453