G-protein coupled receptor family C group 5 member C; retinoic acid-induced gene 3 protein; RAIG-3 (GPRC5C RAIG3 PSEC0087)

Function: - retinoic acid-inducible G-protein coupled receptor - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the G-protein coupled receptor 3 family Compartment: - cell membrane - cytoplasmic vesicle membrane - localized in the plasma membrane & perinuclear vesicles - multi-pass membrane protein Alternative splicing: named isoforms=2 Expression: - expression is highest in the stomach, kidney, liver, pancreas, & prostate - in brain a) expression is generally lower than in the periphery b) highest expression in cerebellum - expressed in spinal cord, & dorsal root ganglia (DRG) - induced by all-trans retinoic acid (ATRA) Notes: - GPRC5C may provide evidence for interaction(s) between retinoid(s) & G-protein signaling pathway(s)

General

glycoprotein phosphoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 441 aa MW = 48 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: signal sequence {1-23} exoplasmic domain {24-50} transmembrane domain {51-71} cytoplasmic loop {72-85} transmembrane domain {86-106} exoplasmic loop {107-120} transmembrane domain {121-141} cytoplasmic loop {142-155} transmembrane domain {156-176} exoplasmic loop {177-208} MOTIF: N-glycosylation site {N191} transmembrane domain {209-229} cytoplasmic loop {230-241} transmembrane domain {242-262} exoplasmic loop {263-279} transmembrane domain {280-300} cytoplasmic domain {301-441} MOTIF: Tyr phosphorylation site {Y324} Tyr phosphorylation site {Y387} Ser phosphorylation site {S398}

Database Correlations

OMIM 605949 UniProt Q9NQ84 Pfam PF00003 Entrez Gene 55890 Kegg hsa:55890