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G-protein coupled receptor family C group 5 member B; A-69G12.1; retinoic acid-induced gene 2 protein; RAIG-2 (GPRC5B, RAIG2)
Function:
- unknown
- retinoic acid-inducible G-protein coupled receptor
Structure:
- belongs to the G-protein coupled receptor 3 family
Compartment:
- cell membrane
- cytoplasmic vesicle membrane
- localized in the plasma membrane & perinuclear vesicles
- multi-pass membrane protein
Expression:
- expression in kidney, pancreas, testis > brain, heart, prostate, small intestine, & spleen > liver, placenta, skeletal muscle, colon, ovary, & thymus
- not detectable in lung & peripheral leukocytes [3]
- highly expressed in most brain areas
- highest levels observed in corpus callosum, caudate nucleus, putamen, substantia nigra, thalamus, hippocampus
- expressed in spinal cord & in dorsal root ganglia
- in the periphery, expression levels are relatively low, compared to the CNS (this contrasts with statement above)
- strongest expression detected in pancreas, testis, uterus, & stomach
- induced by all-trans retinoic acid (ATRA)
Note:
- uncertain whether Met-1 or Met-9 is the initiator
- GPRC5B may provide evidence for interaction(s) between retinoid(s) & G-protein signaling pathway(s)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 403 aa
MW = 45 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: signal sequence {1-28}
exoplasmic domain {29-56}
MOTIF: N-glycosylation site {N30}
transmembrane domain {57-77}
cytoplasmic loop {78-94}
transmembrane domain {95-115}
exoplasmic loop {116-126}
transmembrane domain {127-147}
cytoplasmic loop {148-162}
transmembrane domain {163-183}
exoplasmic loop {184-199}
transmembrane domain {200-220}
cytoplasmic loop {221-234}
transmembrane domain {235-255}
exoplasmic loop {256-271}
transmembrane domain {272-292}
cytoplasmic domain {293-403}
Database Correlations
OMIM 605948
UniProt Q9NZH0
Pfam PF00003
Entrez Gene 51704
Kegg hsa:51704
References
- OMIM :accession 605948
- UniProt :accession Q9NZH0
- Robbins MJ et al
Molecular cloning and characterization of two novel retinoic
acid-inducible orphan G-protein-coupled receptors (GPRC5B and
GPRC5C).
Genomics. 2000 Jul 1;67(1):8-18.
PMID: 10945465