2-oxoglutarate receptor 1; alpha-ketoglutarate receptor 1; G-protein coupled receptor 80; G-protein coupled receptor 99; P2Y purinoceptor 15; P2Y-like nucleotide receptor; P2Y-like GPCR (OXGR1, GPR80, GPR99, P2RY15, P2Y15)

Function: - receptor for alpha-ketoglutarate - seems to act exclusively through a Gq-mediated pathway Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - detected in kidney > placenta - not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: MW = 38 kD entity length = 337 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-34} MOTIF: N-glycosylation site {N10} N-glycosylation site {N23} transmembrane domain {35-55} cytoplasmic loop {56-69} transmembrane domain {70-90} exoplasmic loop {91-116} MOTIF: cysteine residue {C106} MODIFICATION: cysteine residue {C183} transmembrane domain {117-137} cytoplasmic loop {138-151} transmembrane domain {152-172} exoplasmic loop {173-201} MOTIF: N-glycosylation site {N176} N-glycosylation site {N179} cysteine residue {C183} MODIFICATION: cysteine residue {C106} transmembrane domain {202-222} cytoplasmic loop {223-242} transmembrane domain {243-263} exoplasmic loop {264-284} transmembrane domain {285-305} cytoplasmic domain {306-337}

Database Correlations

OMIM 606922 UniProt Q96P68 Pfam PF00001 Kegg hsa:2719

References

UniProt :accession Q96P68