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G-protein coupled receptor 182; adrenomedullin receptor (GPR182, ADMR)
Function: orphan receptor
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- highly expressed in heart, skeletal muscle, immune system, adrenal gland & liver
Note:
- originally thought to be a receptor for adrenomedullin [2]
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 404 aa
MW = 45 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-57}
MOTIF: N-glycosylation site {N28}
N-glycosylation site {N37}
transmembrane domain {58-79}
cytoplasmic loop {80-90}
transmembrane domain {91-113}
exoplasmic loop {114-127}
MOTIF: cysteine residue {C126}
MODIFICATION: cysteine residue {C202}
transmembrane domain {128-149}
cytoplasmic loop {150-170}
transmembrane domain {171-193}
exoplasmic loop {194-217}
MOTIF: cysteine residue {C202}
MODIFICATION: cysteine residue {C126}
transmembrane domain {218-239}
cytoplasmic loop {240-258}
transmembrane domain {259-280}
exoplasmic loop {281-299}
transmembrane domain {300-320}
cytoplasmic domain {321-404}
Database Correlations
OMIM 605307
UniProt O15218
Pfam PF00001
Entrez Gene 11318
Kegg hsa:1131
References
- UniProt :accession O15218
- Hanze J et al
Molecular cloning of a novel human receptor gene with
homology to the rat adrenomedullin receptor and high
expression in heart and immune system.
Biochem Biophys Res Commun. 1997 Nov 7;240(1):183-8
PMID: 9367907