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G-protein coupled receptor 125 (GPR125)
Function:
- orphan receptor
- interacts with DLG1 through its PDZ-binding motif
Structure:
- belongs to the G-protein coupled receptor 2 family, LN-TM7 subfamily
- contains 1 GPS domain
- contains 1 Ig-like domain (immunoglobulin-like)
- contains 5 LRR repeats (leucine-rich repeats)
Compartment: cell membrane
Alternative splicing: named isoforms=4
General
glycoprotein
orphan receptor
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 146 kD
entity length = 1321 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-761}
MOTIF: signal sequence {1-33}
leucine-rich repeat
SITE: 79-103
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N81}
N-glycosylation site {N98}
leucine-rich repeat (3)
SITE: 104-175
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N159}
N-glycosylation site {N206}
Thr phosphorylation site {T208}
immunoglobulin superfamily domain {242-340}
MOTIF: N-glycosylation site {N301}
N-glycosylation site {N332}
N-glycosylation site {N433}
N-glycosylation site {N453}
N-glycosylation site {N592}
leucine-rich repeat
SITE: 594-620
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N652}
N-glycosylation site {N687}
GPS {698-749}
N-glycosylation site {N728}
transmembrane domain {762-782}
cytoplasmic loop {783-796}
transmembrane domain {797-817}
exoplasmic loop {818-826}
MOTIF: N-glycosylation site {N821}
transmembrane domain {827-847}
cytoplasmic loop {848-876}
transmembrane domain {877-897}
exoplasmic loop {898-919}
transmembrane domain {920-940}
cytoplasmic loop {941-996}
transmembrane domain {997-1017}
exoplasmic loop {1018-1024}
transmembrane domain {1025-1045}
cytoplasmic domain {1046-1321}
MOTIF: PDZ recognition motif
NAME: PDZ recognition motif
SITE: 1319-1321
FOR-BINDING-VIA: PDZ domain
Database Correlations
UniProt Q8IWK6
PFAM correlations
References
UniProt :accession Q8IWK6