Search
G-protein coupled bile acid receptor 1 (membrane-type receptor for bile acids, M-BAR, hGPCR19, BG37, hBG37, GPBAR1, TGR5)
Function:
1) receptor for bile acids
2) bile acid-binding induces internalization, activation of extracellular signal-regulated kinase & intracellular cAMP production
3) suppression of macrophage functions by bile acids
Compartment: cell membrane
Expression:
- ubiquitously expressed
- expressed in spleen, placenta > other tissues
- in digestive tissues, wxpressed in stomach, duodenum, jejunum, ileum, cecum, ascending colon, transverse colon, descending colon, liver
- NOT expressed in esophagus or rectum
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: MW = 35 kD
entity length = 330 aa
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-19}
MOTIF: N-glycosylation site {N4}
transmembrane domain {20-40}
cytoplasmic loop {41-50}
transmembrane domain {51-71}
exoplasmic loop {72-85}
MOTIF: N-glycosylation site {N76}
cysteine residue {C85}
MODIFICATION: cysteine residue {C155}
transmembrane domain {86-106}
cytoplasmic loop {107-125}
transmembrane domain {126-146}
exoplasmic loop {147-165}
MOTIF: cysteine residue {C155}
MODIFICATION: cysteine residue {C85}
transmembrane domain {166-186}
cytoplasmic loop {187-228}
transmembrane domain {229-249}
exoplasmic loop {250-261}
transmembrane domain {262-282}
cytoplasmic domain {283-330}
Database Correlations
UniProt Q8TDU6
Pfam PF00001
References
UniProt :accession Q8TDU6