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guanylin; guanylate cyclase activator 2A; guanylate cyclase-activating protein 1; gap-I; contains: HMW-guanylin; contains: guanylin (GUCA2A, GUCA2)
Function:
- endogenous activator of intestinal guanylate cyclase
- stimulates intestinal guanylate cyclase through the same receptor binding region as the heat-stable enterotoxins
Structure: belongs to the guanylin family
Compartment: secreted
Expression:
- highly expressed in ileum & colon
- found in plasma
General
secreted protein
Properties
SIZE: entity length = 115 aa
MW = 12 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C69}
MODIFICATION: cysteine residue {C82}
cysteine residue {C82}
MODIFICATION: cysteine residue {C69}
cysteine residue {C104}
MODIFICATION: cysteine residue {C112}
cysteine residue {C107}
MODIFICATION: cysteine residue {C115}
cysteine residue {C112}
MODIFICATION: cysteine residue {C104}
cysteine residue {C115}
MODIFICATION: cysteine residue {C107}
Database Correlations
OMIM 139392
UniProt Q02747
Pfam PF02058
Entrez Gene 2980
Kegg hsa:2980
References
UniProt :accession Q02747