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guanylate cyclase activator 2B; contains: guanylate cyclase C-activating peptide 2; guanylate cyclase C-activating peptide II; GCAP-II; uroguanylin; UGN (GUCA2B)
Function:
1) endogenous activator of intestinal guanylate cyclase
3) stimulates guanylate cyclase through the same receptor binding region as heat-stable enterotoxins
4) physiological regulator of intestinal fluid & electrolyte transport
5) autocrine/paracrine regulator of intestinal salt & water transport.
Compartment: secreted
Expression: stomach & intestine
General
secreted protein
Properties
SIZE: entity length = 112 aa
MW = 12 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
cysteine residue {C67}
MODIFICATION: cysteine residue {C80}
cysteine residue {C80}
MODIFICATION: cysteine residue {C67}
cysteine residue {C100}
MODIFICATION: cysteine residue {C108}
cysteine residue {C103}
MODIFICATION: cysteine residue {C111}
cysteine residue {C108}
MODIFICATION: cysteine residue {C100}
cysteine residue {C111}
MODIFICATION: cysteine residue {C103}
Database Correlations
OMIM 601271
UniProt Q16661
Pfam PF02058
Entrez Gene 2981
Kegg hsa:2981
References
UniProt :accession Q16661