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brefeldin A-inhibited guanine nucleotide-exchange protein 1; brefeldin A-inhibited GEP 1; p200 ARF-GEP1; p200 ARF guanine nucleotide exchange factor (ARFGEF1, ARFGEP1, BIG1)
Function:
- promotes guanine-nucleotide exchange on ARF1 & ARF3
- promotes activation of ARF1/ARF3 through replacement of GDP with GTP
- inhibited by brefeldin A
- interacts with FKBP2
- interacts with DPY30
Structure: contains 1 SEC7 domain
Expression:
- expressed in placenta, lung, heart, brain, kidney & pancreas
Related
brefeldin A
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 1849 aa
MW = 209 kD
MOTIF: Ser phosphorylation site {S52}
Ser phosphorylation site {S397}
sec7 domain
SITE: 709-840
Ser phosphorylation site {S1569}
Database Correlations
OMIM 604141
UniProt Q9Y6D6
PFAM correlations
Entrez Gene 10565
Kegg hsa:10565
References
UniProt :accession Q9Y6D6