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protein SOLO (SOLO, ARHGEF40)
Function:
- may act as a guanine nucleotide exchange factor (GEF)
Structure:
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
Compartment:
- cytoplasm
- concentrated in the perinuclear region
Alternative splicing: named isoforms=4
Expression:
- expressed at high level in the central nervous system & skeletal muscle
- greater abundance in fetal than adult brain (at protein level)
Related
SEC14 domain & spectrin repeat-containing protein 1 (huntingtin-interacting protein-like protein, protein solo, SESTD1, SOLO)
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 1519 aa
MW = 165 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: glycine-rich region {276-395}
glutamate-rich region {706-711}
MOTIF: glutamate residue (SEVERAL)
coiled coil {828-871}
coiled coil {934-961}
arginine-rich region {966-969}
MOTIF: arginine residue (SEVERAL)
Dbl homology domain {1085-1253}
PH domain {1265-1372}
Database Correlations
UniProt Q8TER5
Kegg hsa:5570
References
UniProt :accession Q8TER5