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guanine nucleotide exchange factor MSS4 (Rab-interacting factor, RABIF, MSS4, RASGRF3, mammalian suppressor of sec4)
Function:
1) guanine-nucleotide-releasing protein, stimulates GDP release
2) acts on members of the SCE4/YPT1/RAB subfamily
3) less active on YPT1 & RAB3A than on SEC4
4) role in vesicular transport
Expression: ubiquitous
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
metalloprotein
Properties
SIZE: MW = 14 kD
entity length = 123 aa
MOTIF: Zn+2-binding site
SITE: 23-23
Zn+2-binding site
SITE: 26-26
Zn+2-binding site
SITE: 94-94
Zn+2-binding site
SITE: 97-97
Database Correlations
OMIM 603417
UniProt P47224
Pfam PF04421
References
- UniProt :accession P47224
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209