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guanine nucleotide exchange factor MCF2L2 (MCF2-transforming sequence-like protein 2, Dbs-related Rho family guanine nucleotide exchange factor, MCF2L2, DRG, KIAA0861)
Function:
- probably functions as guanine nucleotide exchange factor
Structure:
- belongs to the MCF2 family
- contains 1 CRAL-TRIO domain
- contains 1 DH (DBL-homology) domain
- contains 1 PH domain
- contains 1 spectrin repeat
Alternative splicing: named isoforms=4
Expression:
- expressed in brain > pancreas, brain & testis
Pathology:
- genetic variation in MCF2L2 may be associated with susceptibility to diabetes mellitus type-2
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 1114 aa
MW = 127 kD
MOTIF: CRAL-TRIO lipid binding domain {11-193}
Spectrin {323-428}
Dbl homology domain {619-822}
PH domain {834-954}
Database Correlations
OMIM 125853
UniProt Q86YR7
PFAM correlations
Kegg hsa:2310
References
UniProt :accession Q86YR7