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guanine nucleotide exchange factor for Rab3A (Rab3A-interacting-like protein 1, Rabin3-like , RAB3IL1)
Function:
- guanine nucleotide exchange factor (GEF) for Rab3A, a GTPase that regulates synaptic vesicle exocytosis (putative)
- interacts with Rab3A & IHPK1 through the coiled coil domain (competitive, IHPK1 kinase activity not required)
Structure: belongs to the SEC2 family
Alternative splicing: named isoforms=2
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 382 aa
MW = 43 kD
MOTIF: coiled coil {73-161}
Database Correlations
UniProt Q8TBN0
Pfam PF06428
References
UniProt :accession Q8TBN0