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guaifenesin (Robitussin, Fenesin, Humibid LA, Mucinex)

Tradenames: Robitussin, Fenesin, Humibid LA. Indications: - temporary relief of cough due to colds & upper respiratory tract infections - rhinitis, rhinorrhea, nasal congestion, sneezing - relief from allergies - allergic rhinitis, pruritus, urticaria [8] - allergic conjunctivitis [8] - used for fibromyalgia [4] - nausea/vomiting, motion sickness, vertigo [8] - insomnia [8] Contraindications: -> NOT for persistent cough, smoking, asthma, emphysema or cough accompanied by excessive secretions Dosage: 1) adults & children > 12 years of age a) 5-20 mL PO every 4 hours b) 600-1200 mg PO every 12 hours c) maximum 2400 mg QD 2) children 6-12 years of age a) 5-10 mL/dose b) 600 mg PO every 12 hours c) maximum 1200 mg QD 3) children 2-6 years of age -> 2.5 to 5 mL PO 4) increase fluid intake to help loosen mucus Tabs (sustained-release): 600 mg Mucinex (OTC) Syrup: 100 mg/5 mL. Adverse effects: -> not common (1-10%) -> drowsiness, headache, rash, nausea/vomiting, epigastric pain Mechanism of action: 1) expectorant action through increased output of respiratory fluid, enhancing flow of less viscid secretion 2) evidence is subjective & not well established

Interactions

drug adverse effects of antitussive agent(s)

General

antitussive agent expectorant

Properties

MISC-INFO: elimination route LIVER pregnancy-category C safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  4. Prescriber's Letter 7(12):67 2000
  5. Prescriber's Letter 9(9):53 2002
  6. Prescriber's Letter 11(1):3 2004 Detail-Document#: 200102 (subscription needed) http://www.prescribersletter.com
  7. Prescriber's Letter 14(7): 2007 Unapproved Timed-release Guaifenesin Products Detail-Document#: 230706 (subscription needed) http://www.prescribersletter.com
  8. Deprecated Reference

Component-of

acetaminophen/caffeine/chlorpheniramine/guaifenesin acetaminophen/caffeine/chlorpheniramine/guaifenesin/n methylephedrine acetaminophen/caffeine/guaifenesin/phenylephrine acetaminophen/chlorpheniramine/dextromethorphan/guaifenesin acetaminophen/chlorpheniramine/dextromethorphan/guaifenesin/phenylephrine acetaminophen/chlorpheniramine/ephedrine/guaifenesin acetaminophen/chlorpheniramine/guaifenesin acetaminophen/chlorpheniramine/guaifenesin/phenylephrine acetaminophen/codeine/guaifenesin/phenylephrine acetaminophen/codeine/guaifenesin/pseudoephedrine acetaminophen/dextromethorphan/diphenhydramine/guaifenesin acetaminophen/dextromethorphan/diphenhydramine/guaifenesin/phenylephrine acetaminophen/dextromethorphan/doxylamine/guaifenesin acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine acetaminophen/dextromethorphan/doxylamine/guaifenesin/pseudoephedrine acetaminophen/dextromethorphan/guaifenesin acetaminophen/dextromethorphan/guaifenesin/phenylephrine acetaminophen/dextromethorphan/guaifenesin/pseudoephedrine acetaminophen/dextromethorphan/guaifenesin/zinc acetate/zinc gluconate acetaminophen/dextromethorphan/guaifenesin/zinc sulfate acetaminophen/diphenhydramine/guaifenesin/phenylephrine acetaminophen/ephedrine/guaifenesin acetaminophen/guaifenesin acetaminophen/guaifenesin/phenylephrine acetaminophen/guaifenesin/pseudoephedrine brompheniramine/codeine/guaifenesin brompheniramine/dextromethorphan/guaifenesin brompheniramine/dextromethorphan/guaifenesin/phenylephrine brompheniramine/dextromethorphan/guaifenesin/pseudoephedrine brompheniramine/guaifenesin/hydrocodone brompheniramine/guaifenesin/phenylephrine carbetapentane/citrate/guaifenesin carbetapentane/citrate/guaifenesin/phenylephrine carbetapentane/diethylcarbamazine/guaifenesin/phenylephrine carbetapentane/guaifenesin carbetapentane/guaifenesin/phenylephrine carbetapentane/guaifenesin/pseudoephedrine carbohydrate/dextromethorphan/guaifenesin chlophedianol/guaifenesin chlophedianol/guaifenesin/phenylephrine chlophedianol/guaifenesin/pseudoephedrine chlorpheniramine/dextromethorphan/guaifenesin chlorpheniramine/dextromethorphan/guaifenesin/methscopolamine/phenylephrine chlorpheniramine/dextromethorphan/guaifenesin/phenylephrine chlorpheniramine/dextromethorphan/guaifenesin/pseudoephedrine chlorpheniramine/guaifenesin/hydrocodone/pseudoephedrine chlorpheniramine/guaifenesin/methscopolamine/phenylephrine chlorpheniramine/guaifenesin/phenylephrine chlorpheniramine/guaifenesin/phenylpropanolamine citrate/dextromethorphan/guaifenesin citrate/dextromethorphan/guaifenesin/pyrilamine citrate/guaifenesin citrate/guaifenesin/phenylephrine codeine/diethylcarbamazine/guaifenesin/pseudoephedrine codeine/guaifenesin (Robitussin AC) codeine/guaifenesin/phenylephrine codeine/guaifenesin/phenylephrine/phosphate codeine/guaifenesin/phosphate codeine/guaifenesin/phosphate/pseudoephedrine codeine/guaifenesin/promethazine codeine/guaifenesin/pseudoephedrine (Robitussin DAC) d/guaifenesin/pseudoephedrine dexbrompheniramine/dextromethorphan/guaifenesin/phenylephrine dexbrompheniramine/dextromethorphan/guaifenesin/pseudoephedrine dexchlorpheniramine/dextromethorphan/guaifenesin/phenylephrine dexchlorpheniramine/guaifenesin/pseudoephedrine dextromethorphan/diphenhydramine/guaifenesin dextromethorphan/diphenhydramine/guaifenesin/phenylephrine dextromethorphan/doxylamine/guaifenesin dextromethorphan/guaiacolsulfonate/guaifenesin dextromethorphan/guaifenesin (Robitussin DM, Naldecon Dx) dextromethorphan/guaifenesin/nov protein/pseudoephedrine dextromethorphan/guaifenesin/phenylephrine dextromethorphan/guaifenesin/phenylpropanolamine dextromethorphan/guaifenesin/phenylpropanolamine/pyrilamine dextromethorphan/guaifenesin/pseudoephedrine (Robitussin CF) dextromethorphan/guaifenesin/ribonuclease/angiogenin inhibitor diethylcarbamazine/guaifenesin/phenylephrine diethylcarbamazine/guaifenesin/pseudoephedrine dihydrocodeine/guaifenesin dihydrocodeine/guaifenesin/phenylephrine dihydrocodeine/guaifenesin/pseudoephedrine diphenhydramine/guaifenesin diphenhydramine/guaifenesin/phenylephrine dyphylline/ephedrine/guaifenesin/phenobarbital dyphylline/guaifenesin ephedrine/guaifenesin guaiacolsulfonate/guaifenesin (Humibid LA) guaifenesin/hydrocodone guaifenesin/hydrocodone/phenylephrine guaifenesin/hydrocodone/pseudoephedrine guaifenesin/hydromorphone guaifenesin/nov protein/pseudoephedrine guaifenesin/p21rho g/phenylephrine guaifenesin/phenylephrine guaifenesin/phenylephrine/phenylpropanolamine (Entex) guaifenesin/phenylephrine/pyrilamine guaifenesin/phenylephrine/zinc acetate guaifenesin/phenylpropanolamine (Entex LA, Ami-Tex LA) guaifenesin/pseudoephedrine (Entex PSE, Robitussin PE) guaifenesin/pseudoephedrine/theophylline guaifenesin/pyrilamine guaifenesin/theophylline