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GTP cyclohydrolase 1 feedback regulatory protein; GFRP; GTP cyclohydrolase I feedback regulatory protein; p35 (GCHFR, GFRP)
Function:
- mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I
- inhibition is reversed by L-phenylalanine
- forms a complex with GCH1 where a GCH1 homodecamer is sandwiched by two GFRP homopentamers
- interacts with GCH1
Structure:
- homopentamer
- belongs to the GFRP family
Compartment:
- nucleus, nuclear membrane, cytoplasm
Expression:
- in epidermis, expressed predominantly in basal undifferentiated keratinocytes & in some but not all melanocytes (at protein level)
Related
GTP cyclohydrolase (GTP cyclohydrolase 1, GTP dihydrolase, GTP ring-opening enzyme, GTP 8-formylhydrolase, GCH1)
General
nuclear protein
Properties
SIZE: entity length = 84 aa
MW = 10 kD
COMPARTMENT: cytoplasm
cell nucleus
Database Correlations
OMIM 602437
UniProt P30047
Pfam PF06399
Entrez Gene 2644
Kegg hsa:2644
References
UniProt :accession P30047