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GTP-binding protein REM 1; GTPase-regulating endothelial cell sprouting; Rad & Gem-like GTP-binding protein 1 (REM1, GES, REM)
Function:
1) endothelial cell sprouting
2) actin cytoskeletal reorganization
3) angiogenesis.
4) Ca+2 signaling.
5) interacts with calmodulin
Structure: belongs to the small GTPase superfamily, RGK family
Expression:
1) endothelial lining of blood vessels in uterus, heart
2) lower levels found in spleen, lymph node, kidney, testis
3) cells with secretory functio
a) islets of Langerhans, acinar cells in the pancreas
b) duct epithelium in the breast
c) bile duct epithelium
d) colon mucosa
e) prostate
General
cytoskeletal protein
guanine nucleotide regulatory protein (GNRP)
phosphoprotein
Properties
SIZE: entity length = 298 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S18}
GTP-binding site
SITE: 87-94
GTP-binding site
SITE: 195-198
arginine-rich region {241-288}
MOTIF: arginine residue (SEVERAL)
calmodulin binding site
SITE: 268-287
FOR-BINDING-OF: calmodulin
Database Correlations
OMIM 610388
UniProt O75628
Pfam PF00071
Entrez Gene 28954
Kegg hsa:28954
References
UniProt :accession O75628