GTP-binding protein 10 (protein obg homolog 2, ObgH2, GTPBP10, OBGH2, UG0751c10)

Function: - role in the ribosome maturation process - role of GTPase in vitro. - when missing, disorganization of the nuceleolar architecture is observed Structure: belongs to the GTP1/OBG family Compartment: - nucleus, nucleolus - found in the dense fibrillar compartment region of nucleolus - at onset of mitosis, moves to chromosome surface & remains there until anaphase - gradually re-assembles into the nucleolus at late anaphase to telophase Alternative splicing: named isoforms=3

General

guanine nucleotide regulatory protein (GNRP) nuclear protein

Properties

SIZE: entity length = 387 aa MW = 43 kD COMPARTMENT: cell nucleus MOTIF: GTP-binding site SITE: 155-162 GTP-binding site SITE: 202-206 GTP-binding site SITE: 278-281

Database Correlations

UniProt A4D1E9 PFAM correlations

References

UniProt :accession A4D1E9