growth hormone secretagogue receptor type 1; GHS-R; GH-releasing peptide receptor; GHRP; ghrelin receptor (GHSR)

Function: - receptor for ghrelin - coupled to G-alpha-11 proteins - stimulates growth hormone secretion - also binds other growth hormone releasing peptides (GHRP) (Met-enkephalin & GHRP-6) as well as non-peptide, LMW secretagogues (L-692,429, MK-0677, adenosine) Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Alternative splicing: named isoforms=2; 1A,1B Expression: pituitary & hypothalamus Pathology: - defects in GHSR may be a cause of short stature

General

glycoprotein G-protein coupled receptor; serpentine receptor

Properties

SIZE: entity length = 366 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-40} MOTIF: N-glycosylation site {N13} N-glycosylation site {N27} transmembrane domain {41-66} cytoplasmic loop {67-72} transmembrane domain {73-96} exoplasmic loop {97-117} MOTIF: cysteine residue {C116} MODIFICATION: cysteine residue {C198} transmembrane domain {118-139} cytoplasmic loop {140-162} transmembrane domain {163-183} exoplasmic loop {184-211} MOTIF: cysteine residue {C198} MODIFICATION: cysteine residue {C116} transmembrane domain {212-235} cytoplasmic loop {236-263} transmembrane domain {264-285} exoplasmic loop {286-302} transmembrane domain {303-326} cytoplasmic domain {327-366}

Database Correlations

OMIM correlations UniProt Q92847 Pfam PF00001 Kegg hsa:2693

References

UniProt :accession Q92847