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growth hormone-releasing hormone receptor; GHRH receptor; GRF receptor; GRFR (GHRHR)
Function:
- receptor for GRF
- coupled to G proteins which activate adenylyl cyclase
- stimulates somatotroph cell growth, growth hormone gene transcription & growth hormone secretion
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane
Expression: pituitary gland
Pathology:
- defects in GHRHR are a cause of isolated growth hormone deficiency type 1B
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 423 aa
MW = 47 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {23-132}
MOTIF: signal sequence {1-22}
N-glycosylation site {N50}
transmembrane domain {133-152}
cytoplasmic loop {153-162}
transmembrane domain {163-181}
exoplasmic loop {182-204}
transmembrane domain {205-227}
cytoplasmic loop {228-240}
transmembrane domain {241-262}
exoplasmic loop {263-280}
transmembrane domain {281-304}
cytoplasmic loop {305-329}
transmembrane domain {330-348}
exoplasmic loop {349-361}
transmembrane domain {362-381}
cytoplasmic domain {382-423}
Database Correlations
OMIM correlations
MORBIDMAP 139191
UniProt Q02643
PFAM correlations
Kegg hsa:2692
References
UniProt :accession Q02643