growth arrest-specific protein 2; GAS-2 (GAS2)

Function: - may play a role in apoptosis by acting as a cell death substrate for caspases - cleaved during apoptosis; the cleaved form induces rearrangements of actin cytoskeleton & changes in the shape of the affected cells - may be involved in the membrane ruffling process - cleaved, during apoptosis, on a specific Asp by caspases - phosphorylated on Ser during the G0-G1 transition phase (putative) - component of the microfilament system Structure: - belongs to the GAS2 family - contains 1 CH (calponin-homology) domain - contains 1 GAR domain Compartment: - cytoplasm, cytoskeleton (putative) - membrane; peripheral membrane protein (putative) - colocalizes with actin fibers at the cell border & along stress fibers in growth-arrested fibroblasts - mainly membrane-associated - when hyperphosphorylated, accumulates at membrane ruffles Expression: - ubiquitously expressed with highest levels in liver, lung, & kidney - not found in spleen - specifically expressed at growth arrest

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 313 aa MW = 35 kD COMPARTMENT: cytoplasm MOTIF: calponin homology domain NAME: calponin homology domain SITE: 34-156 GAR {197-270} proteolytic site {278-279} Ser phosphorylation site {S282}

Database Correlations

OMIM 602835 UniProt O43903 PFAM correlations Entrez Gene 2620 Kegg hsa:2620

References

UniProt :accession O43903