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DNA damage-inducible transcript 3; DDIT-3; growth arrest & DNA-damage-inducible protein GADD153; C/EBP-homologous protein; CHOP (DDIT3, CHOP, GADD153)
Function:
- inhibits the DNA-binding activity of C/EBP & LAP by forming heterodimers that cannot bind DNA
Structure:
- belongs to the bZIP family
- contains 1 bZIP domain
Compartment: nucleus
Pathology:
- chromosomal translocation t(12;16)(q13;p11) involving DDIT3 with FUS is found in a form of malignant myxoid liposarcoma
Related
CHOP gene
General
nuclear protein
Properties
SIZE: entity length = 169 aa
MW = 19 kD
COMPARTMENT: cell nucleus
MOTIF: glutamate-rich region {93-97}
MOTIF: glutamate residue (SEVERAL)
leucine zipper
SITE: 134-148
FOR-BINDING-VIA: leucine zipper
Database Correlations
OMIM correlations
UniProt P35638
Pfam PF07716
Entrez Gene 1649
Kegg hsa:1649
References
- UniProt :accession P35638
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/DDIT3ID80.html
- NIEHS-SNPs
http://egp.gs.washington.edu/data/ddit3/