growth arrest & DNA-damage-inducible proteins-interacting protein 1 (CR6-interacting factor 1, CRIF1, CK2 beta-associating protein, papillomavirus L2-interacting nuclear protein 1, PLINP-1, GADD45GIP1, PLINP1)

Function: - negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases - inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins - cells overexpressing GADD45GIP1 were more likely to be in G1 & less likely to be in S phase & grow more slowly than control cells - inhibiting the expression of GADD45GIP1 promotes cell cycle progression - repressor of orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity - role in hormone-mediated regulation of NR4A1 transcriptional activity (putative) - interacts with GADD45A, GADD45B & GADD45G - interacts with NR4A1 via the NR4A1 AB domain - interacts with human papilloma virus type 16 (HPV 16) minor capsid protein L2 Compartment: nucleus Expression: - widely expressed - expressed in thyroid gland, heart, lymph nodes, trachea & adrenal tissues > liver skeletal muscle, kidney, pancreas, testis, ovary & stomach Pathology: - barely detectable in - adrenal adenoma - papillary thyroid cancer

Properties

SIZE: MW = 25 kD entity length = 222 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {99-212} MOTIF: glutamine-rich region {136-139} MOTIF: glutamine residue (SEVERAL) nuclear translocation signal {184-200}

References

UniProt :accession Q8TAE8