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growth/differentiation factor 6 (GDF-6, growth/differentiation factor 16, GDF6, GDF16)
Function:
- required for normal formation of bones & joints in limbs, skull, & axial skeleton
- role in establishing boundaries between skeletal elements during development
Structure:
- homodimer, disulfide-linked
- belongs to the TGF-beta family
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: MW = 51 kD
entity length = 455 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
serine-rich region {27-34}
MOTIF: serine residue (SEVERAL)
N-glycosylation site {N114}
proline-rich region
SITE: 255-258
MOTIF: proline residue (SEVERAL)
arginine-rich region {331-335}
MOTIF: arginine residue (SEVERAL)
cysteine residue {C354}
MODIFICATION: cysteine residue {C420}
cysteine residue {C383}
MODIFICATION: cysteine residue {C452}
cysteine residue {C387}
MODIFICATION: cysteine residue {C454}
cysteine residue {C419}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C420}
MODIFICATION: cysteine residue {C354}
cysteine residue {C452}
MODIFICATION: cysteine residue {C383}
cysteine residue {C454}
MODIFICATION: cysteine residue {C387}
Database Correlations
UniProt Q6KF10
PFAM correlations
References
UniProt :accession Q6KF10