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group 2E secretory phospholipase A2; GIIE sPLA2; sPLA2-IIE; phosphatidylcholine 2-acylhydrolase 2E (PLA2G2E)
Function:
- catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
- preference for arachidonic-containing phospholipids
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Cofactor: binds 1 Ca+2 per subunit
Structure: belongs to the phospholipase A2 family
Compartment: secreted
Expression:
- expression restricted to brain, heart, lung, & placenta
General
Ca+2 binding protein
glycoprotein
phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
secreted protein
Properties
SIZE: entity length = 142 aa
MW = 16 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
cysteine residue {C44}
MODIFICATION: cysteine residue {C135}
Ca+2-binding site
SITE: 45-45
cysteine residue {C46}
MODIFICATION: cysteine residue {C62}
Ca+2-binding site
SITE: 47-47
Ca+2-binding site
SITE: 49-49
cysteine residue {C61}
MODIFICATION: cysteine residue {C115}
cysteine residue {C62}
MODIFICATION: cysteine residue {C46}
histidine residue {H65}
Ca+2-binding site
SITE: 66-66
cysteine residue {C67}
MODIFICATION: cysteine residue {C142}
cysteine residue {C68}
MODIFICATION: cysteine residue {C108}
cysteine residue {C77}
MODIFICATION: cysteine residue {C101}
cysteine residue {C95}
MODIFICATION: cysteine residue {C106}
cysteine residue {C101}
MODIFICATION: cysteine residue {C77}
cysteine residue {C106}
MODIFICATION: cysteine residue {C95}
cysteine residue {C108}
MODIFICATION: cysteine residue {C68}
aspartate residue {D109}
cysteine residue {C115}
MODIFICATION: cysteine residue {C61}
cysteine residue {C135}
MODIFICATION: cysteine residue {C44}
cysteine residue {C142}
MODIFICATION: cysteine residue {C67}
Database Correlations
UniProt Q9NZK7
Pfam PF00068
Entrez Gene 30814
Kegg hsa:30814
ENZYME 3.1.1.4
References
UniProt :accession Q9NZK7