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group 12A secretory phospholipase A2; GXII sPLA2; sPLA2-XII; phosphatidylcholine 2-acylhydrolase 12A (PLA2G12A, PLA2G12, FKSG38, UNQ2519/PRO6012)
Function:
- catalyzes Ca+2-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides
- no detectable activity toward sn-2-arachidonoyl- or linoleoyl- phosphatidylcholine or -phosphatidylethanolamine
phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure: belongs to the phospholipase A2 family
Compartment: secreted. cytoplasm
Expression:
- abundantly expressed in heart, skeletal muscle, kidney, liver & pancreas
General
Ca+2 binding protein
glycoprotein
phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
secreted protein
Properties
SIZE: entity length = 189 aa
MW = 21 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-22}
Ca+2-binding site
SITE: 88-88
Ca+2-binding site
SITE: 90-90
Ca+2-binding site
SITE: 92-92
histidine residue {H110}
Ca+2-binding site
SITE: 111-111
aspartate residue {D125}
Database Correlations
OMIM 611652
UniProt Q9BZM1
Pfam PF06951
Entrez Gene 81579
Kegg hsa:81579
ENZYME 3.1.1.4
References
UniProt :accession Q9BZM1