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GrimAge; DNAm GrimAge
- GrimAge is a composite biomarker of aging based on 7 or 8 DNA methylation surrogates including a DNA methylation-based estimate of smoking pack-years [1]
- GrimAge is an epigenetic clock with predictive ability for life expectancy
- GrimAge estimates of levels of plasma proteins including
- plasminogen activator inhibitor 1 (PAI-1) [1]
- growth differentiation factor 15 (GDF15) [1]
- C-reactive protein (CRP) [2]
General
DNA methylation (promoter methylation)
biomarker of aging
References
- Lu AT, Quach A, Wilson JG et al
DNA methylation GrimAge strongly predicts lifespan and healthspan.
Aging (Albany NY). 2019 Jan 21;11(2):303-327.
PMID: 30669119 PMCID: PMC6366976 Free PMC article.
- Lu AT, Binder AM, Zhang J et al
DNA methylation GrimAge version 2.
Aging (Albany NY). 2022 Dec 14;14(23):9484-9549.
PMID: 36516495 PMCID: PMC9792204 Free PMC article.