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amino-terminal enhancer of split; amino enhancer of split; GRG protein; protein ESP1; Gp130-associated protein GAM (AES, GRG)
Function:
- acts as dominant repressor towards other family members
- inhibits NF-kappa-B-regulated gene expression
- may be required for initiation & maintenance of cellular differentiation
- homooligomer & heterooligomer with other family members
- binds TCF7 (putative)
- binds the NF-kappa-B subunit RELA
- interacts with PHF12
Structure:
- lacks the C-terminal WD repeats
- belongs to the WD repeat groucho/TLE family
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression:
- found predominantly in muscle, heart & placenta
- in fetal tissues, abundantly expressed in the heart, lung, kidney, brain & liver
General
nuclear protein
Properties
SIZE: entity length = 197 aa
MW = 22 kD
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {1-131}
MOTIF: glutamine residue (SEVERAL)
proline-rich region
SITE: 132-165
MOTIF: proline residue (SEVERAL)
CCN {166-197}
Database Correlations
OMIM 600188
UniProt Q08117
Pfam PF03920
Entrez Gene 166
Kegg hsa:166
References
UniProt :accession Q08117