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GRIP1-associated protein 1; GRASP-1 (GRIPAP1 ,KIAA1167)
Function:
- guanine nucleotide exchange factor for the ras family of G proteins [1]
- proteolytically cleaved by caspase-3 (putative)
- interacts with GRIP1, GRIP2 & AMPA receptors
Compartment: early endosome [2]
Alternative splicing: named isoforms=4
Expression:
- neuron-specific [1]
Pathology:
- antibodies against GRIPAP1 have been found in sera of a patient who developed Raynaud's syndrome & telangiectasias
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
phosphoprotein
Properties
SIZE: entity length = 841 aa
MW = 96 kD
MOTIF: coiled coil {4-161}
coiled coil {208-641}
MOTIF: proteolytic site {598-599}
Ser phosphorylation site {S655}
Ser phosphorylation site {S666}
Ser phosphorylation site {S669}
Ser phosphorylation site {S690}
Ser phosphorylation site {S692}
coiled coil {701-735}
coiled coil {785-814}
Database Correlations
OMIM 300408
UniProt Q4V328
Entrez Gene 56850
Kegg hsa:56850
References
- OMIM :accession 300408
- UniProt :accession Q4V328