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granzyme-M; lymphocyte met-ase 1; natural killer cell granular protease; HU-Met-1; Met-1 serine protease (GZMM, MET1)
Function:
- cleaves peptide substrates after Met, Leu & norleucine
Structure:
- belongs to the peptidase S1 family, Granzyme subfamily
- contains 1 peptidase S1 domain
Compartment:
- secreted. cytoplasmic granule
- granules of large granular lymphocytes
General
glycoprotein
granzyme, cytotoxic T-cell protease; CTL tryptase; fragmentin
Properties
SIZE: entity length = 257 aa
MW = 27 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-23}
S1 domain {26-254}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C67}
histidine residue {H66}
cysteine residue {C67}
MODIFICATION: cysteine residue {C51}
aspartate residue {D111}
cysteine residue {C145}
MODIFICATION: cysteine residue {C213}
cysteine residue {C176}
MODIFICATION: cysteine residue {C192}
N-glycosylation site {N177}
cysteine residue {C192}
MODIFICATION: cysteine residue {C176}
cysteine residue {C203}
MODIFICATION: cysteine residue {C230}
serine residue {S207}
cysteine residue {C213}
MODIFICATION: cysteine residue {C145}
cysteine residue {C230}
MODIFICATION: cysteine residue {C203}
Database Correlations
OMIM 600311
UniProt P51124
Pfam PF00089
Entrez Gene 3004
Kegg hsa:3004
References
UniProt :accession P51124