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granzyme H; cytotoxic T-lymphocyte proteinase; cathepsin G-like 2; CTSGL2; CCP-X; cytotoxic serine protease C; CSP-C (GZMH, CGL2, CTSGL2)
Function:
- probably necessary for target cell lysis in cell-mediated immune responses
Structure:
- belongs to the peptidase S1 family, Granzyme subfamily
- contains 1 peptidase S1 domain
Compartment:
- cytoplasmic granule
- cytoplasmic granules of cytolytic T-lymphocytes
General
glycoprotein
granzyme, cytotoxic T-cell protease; CTL tryptase; fragmentin
Properties
SIZE: entity length = 246 aa
MW = 27 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-18}
S1 domain {21-244}
MOTIF: cysteine residue {C49}
MODIFICATION: cysteine residue {C65}
histidine residue {H64}
cysteine residue {C65}
MODIFICATION: cysteine residue {C49}
N-glycosylation site {N71}
N-glycosylation site {N104}
aspartate residue {D108}
cysteine residue {C142}
MODIFICATION: cysteine residue {C208}
cysteine residue {C172}
MODIFICATION: cysteine residue {C187}
N-glycosylation site {N179}
cysteine residue {C187}
MODIFICATION: cysteine residue {C172}
serine residue {S202}
cysteine residue {C208}
MODIFICATION: cysteine residue {C142}
Database Correlations
OMIM 116831
UniProt P20718
Pfam PF00089
Entrez Gene 2999
Kegg hsa:2999
References
UniProt :accession P20718