protein BEX3; brain-expressed X-linked protein 3; p75NTR-associated cell death executor; nerve growth factor receptor-associated protein 1; ovarian granulosa cell 13.0 kD protein HGR74 (NGFRAP1, BEX3, DXS6984E, NADE)

Function: - may be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF - plays a role in Zn+2-triggered neuronal death (putative) - may play an important role in the pathogenesis of neurogenetic diseases - ubiquitinated - degraded by the proteasome (putative) - self-associates - interacts with 14-3-3 epsilon (YWHAE) - interacts with DIABLO/SMAC (putative) - binds to the DEATH - domain of p75NTR/NGFR Structure: the nuclear export signal is required for export from the nucleus & the interactions with itself & p75NTR/NGFR (By similarity) belongs to the BEX family Compartment: nucleus. cytoplasm. Note: shuttles between the cytoplasm & the nucleus. associates with replicating mitochondria (putative) Expression: found in ovarian granulosa cells, testis, prostate & seminal vesicle tissue. high levels also detected in liver Miscellaneous: binds transition metals (putative)

Properties

SIZE: entity length = 111 aa MW = 13 kD COMPARTMENT: mitochondria cytoplasm cell nucleus MOTIF: 14-3-3 epsilon interaction {68-111} MOTIF: p75NTR/NGFR interaction {68-93} peptide motif {77-87}

Database Correlations

OMIM 300361 UniProt Q00994 Pfam PF04538 Entrez Gene 27018 Kegg hsa:27018

References

UniProt :accession Q00994