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grainyhead-like protein 2 homolog (brother of mammalian grainyhead, transcription factor CP2-like 3, GRHL2, BOM, TFCP2L3)
Function:
1) transcription factor
Structure:
- homodimer, also forms heterodimers with GRHL1 or GRHL3
Compartment: nucleus
Alternative splicing: named isoforms=2
Expression:
- expressed in placenta, prostate, brain, kidney > epithelial tissues of thymus, kidney, lung, salivary gland, mammary gland, digestive tract
- expressed in cochlea
Pathology:
- defects in GRHL2 are the cause of autosomal dominant nonsyndromic sensorineural deafness 28
General
transcription factor (TF)
Properties
SIZE: MW = 71 kD
entity length = 625 aa
COMPARTMENT: cell nucleus
MOTIF: transcriptional activation domain
SITE: 1-93
Database Correlations
OMIM correlations
UniProt Q6ISB3
Pfam PF04516
References
UniProt :accession Q6ISB3