grainyhead-like protein 1 homolog (transcription factor CP2-like 2, transcription factor LBP-32, NH32, mammalian grainyhead, GRHL1, LBP32, MGR, TFCP2L2)

Function: - transcription factor - isoform 1 may function as an activator & isoform 2 as a repressor in tissues where both forms are expressed - role in development (putative) - role in epidermal differentiation (putative) - binds & transactivates the EN1 promoter - homodimer, also forms heterodimers with GRHL2 or GRHL3 Structure: belongs to the grh/CP2 family, Grainyhead subfamily Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - isoform 1 is highly expressed in brain, pancreas, tonsil, placenta & kidney - isoform 2 is highly expressed in brain & liver - highly expressed in placental JEG-3 cells & at very low levels in non-steroidogenic cells - no expression detected in adrenal NCI-H295A cells - expressed in fetal liver & brain

Properties

SIZE: MW = 70 kD entity length = 618 aa COMPARTMENT: cell nucleus MOTIF: transcriptional activation domain SITE: 1-93

Database Correlations

UniProt Q9NZI5 Pfam PF04516

References

UniProt :accession Q9NZI5